Long-chain fatty acid transport protein 1 (Protein name
), S27A1_BOVIN from NCBI database.
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General Annotation
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Antigen Annotation
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Predicted Eptitope
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Gene name:
SLC27A1(FATP1);
Protein name:
Long-chain fatty acid transport protein 1(FATP-1;Fatty acid transport protein 1);
Alternative:
Solute carrier family 27 member 1;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Self-associates. May function as an homodimer.
Function:
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids.
Subcellular Location:
Cell membrane
Single-pass membrane protein
Endomembrane system
Single-pass membrane protein
Cytoplasm
Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes.
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Precision
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Recovery
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Linearity
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References
1.
"Bovine solute carrier family 27 member 1 (SLC27A1) gene: structural and functional analysis." Ordovas L.
,
Zaragoza P.
,
Rodellar C.
Submitted (2004-08) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]